61 citations
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January 2008 in “Biological & Pharmaceutical Bulletin” In this study, finasteride dose-dependently inhibited stress-induced increases in allopregnanolone in rats, while enhancing 20alpha-reduction of progesterone without affecting 3alpha-dihydroprogesterone or 11-deoxycorticosterone levels.
26 citations
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November 1993 in “Progress in Neuro-psychopharmacology & Biological Psychiatry” This study reported that prenatal exposure to dihydrotestosterone altered long-term androgen metabolism in juvenile male rats, suggesting different regulatory mechanisms for 5a-reductase in hypothalamic versus pituitary tissues.
233 citations
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November 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” This review explores androgen metabolism in the skin, highlighting enzyme localization and potential implications for treating androgen-dependent skin conditions, but it reports no new clinical results.
23 citations
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May 1984 in “Journal of the American Geriatrics Society” Benign Prostatic Hyperplasia may be caused by changes in how the body processes male hormones.
19 citations
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January 2005 in “Paediatrics and Child Health” This review discusses the features and diagnosis of metabolic syndrome in obese children and reports no new findings, highlighting the need for a uniform pediatric definition and early intervention.