TLDR Stem cells show promise for treating skin conditions and aiding healing.
Stem cells in dermatology were recognized for their ability to self-renew and differentiate into specialized cells, with various niches identified in the skin, including interfollicular, follicular, mesenchymal, and melanocyte stem cells. Although treatment of skin diseases with stem cells was still experimental, research focused on their potential in treating conditions like dystrophic epidermolysis bullosa, systemic lupus erythematosus, vitiligo, various types of alopecia, ulcers, and slow-healing wounds. Their flexibility and differentiation capabilities offered promising possibilities for regenerative medicine.
83 citations
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January 2015 in “World Journal of Stem Cells” Hair follicle regeneration needs special conditions and young cells.
31 citations
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December 2014 in “Advances in Clinical and Experimental Medicine” Stem cells could improve plastic surgery but are not widely used due to cost and safety concerns.
66 citations
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May 2012 in “Scientific Reports” Scientists successfully created and transplanted bioengineered hair follicles that function like natural ones, suggesting a new treatment for hair loss.
52 citations
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October 2005 in “Journal of Investigative Dermatology” Hair follicle stem cells have greater longevity and adhesion, while transit-amplifying cells are more mobile.
177 citations
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November 2002 in “British journal of dermatology/British journal of dermatology, Supplement” Transplantation is effective for stable leucoderma but not for progressive, widespread vitiligo vulgaris.
55 citations
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March 2012 in “Journal of Investigative Dermatology” Research on epidermal stem cells has advanced significantly, showing promise for improved clinical therapies.
43 citations
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January 2012 in “Biological Research” The origins of many adult skin stem cells are still mostly unknown.
232 citations
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October 2015 in “International journal of molecular sciences” Stem cells are crucial for skin repair and new treatments for chronic wounds.
9 citations
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March 2013 in “Expert opinion on biological therapy” Epidermal stem cells have potential for personalized regenerative medicine but need careful handling to avoid cancer.
8 citations
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May 2021 in “Bioengineering & translational medicine” Hair growth environment recreated with challenges; stem cells make successful skin organoids.
16 citations
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December 2006 in “Expert Review of Dermatology” Hair follicles are essential for skin health, aiding in hair growth, wound healing, and immune function.
