Effect of Human Bone Marrow Mesenchymal Stem Cell Administration on Microscopic Features of Adnexal Tissue in Diabetic Burn Wound Rat Skin

November 2022 in “ Jurnal Ilmu Kesehatan Indonesia ”

Jella Wisesa, Gusti Revilla, Yenita Yenita

human bone marrow mesenchymal stem cells hBM-MSC adnexal tissue skin diabetes mellitus burn wounds

Studysummary In this study, human bone marrow mesenchymal stem cells were found to affect skin adnexa growth in diabetic burn-injured rats, but the effects were not statistically significant. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the effect of human bone marrow mesenchymal stem cells (hBM-MSC) on the microscopic appearance of adnexal tissue in the skin of diabetic rats with burn injuries. Using 30 rats divided into control and treatment groups, the research found an increase in the total growth of skin adnexal tissue after administering hBM-MSC. However, there was no significant impact on the average diameter of the tissue growth. Statistical analysis using Two-Way ANOVA showed no significant differences in the total number and average diameter of adnexal tissue growth, with p-values of 0.621 and 0.427, respectively. The conclusion was that while hBM-MSC influenced adnexal tissue growth, the results were not statistically significant.

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