Effect of Human Bone Marrow Mesenchymal Stem Cell Administration on Microscopic Features of Adnexal Tissue in Diabetic Burn Wound Rat Skin

November 2022 in “ Jurnal Ilmu Kesehatan Indonesia ”

Jella Wisesa, Gusti Revilla, Yenita Yenita

human bone marrow mesenchymal stem cells hBM-MSC adnexal tissue skin diabetes mellitus burn wounds

TLDR Human bone marrow stem cells increased skin tissue growth in diabetic rats with burns, but not significantly.

The study investigated the effect of human bone marrow mesenchymal stem cells (hBM-MSC) on the microscopic appearance of adnexal tissue in the skin of diabetic rats with burn injuries. Using 30 rats divided into control and treatment groups, the research found an increase in the total growth of skin adnexal tissue after administering hBM-MSC. However, there was no significant impact on the average diameter of the tissue growth. Statistical analysis using Two-Way ANOVA showed no significant differences in the total number and average diameter of adnexal tissue growth, with p-values of 0.621 and 0.427, respectively. The conclusion was that while hBM-MSC influenced adnexal tissue growth, the results were not statistically significant.

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Effect of Human Bone Marrow Mesenchymal Stem Cell Administration on Microscopic Features of Adnexal Tissue in Diabetic Burn Wound Rat Skin

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research Stem Cell Therapy for Burns: The Story So Far

research Current Advanced Therapies Based on Human Mesenchymal Stem Cells for Skin Diseases

research Functional Hair Follicle Regeneration: An Updated Review

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research Epidermal Growth Factor Promotes Mesenchymal Stem Cell-Mediated Wound Healing and Hair Follicle Regeneration

research Reduced Cell Cohesiveness of Outgrowths from Eccrine Sweat Glands Delays Wound Closure in Elderly Skin

research Wound Healing and Skin Regeneration

research VEGF165 Modulates Proliferation, Adhesion, Migration, and Differentiation of Cultured Human Outer Root Sheath Cells from Central Hair Follicle Epithelium Through VEGFR-2 Activation In Vitro

research Transplantation of Bone-Marrow-Derived Mesenchymal and Epidermal Stem Cells Contribute to Wound Healing with Different Regenerative Features

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