Sostdc1 Defines the Size and Number of Skin Appendage Placodes

    February 2012 in “ Developmental biology ”
    Katja Maria Närhi, Mark Tümmers, Laura Ahtiainen … Marja L. Mikkola
    Studysummary This study found that the absence of Sostdc1 in mice alters mammary gland and hair follicle development, particularly by increasing vibrissae numbers and causing unusual nipple-like structures.
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    Research cited in this study 18

    1. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    2. Conversion of the Nipple to Hair-Bearing Epithelia by Lowering Bone Morphogenetic Protein Pathway Activity at the Dermal-Epidermal Interface ˜The œAmerican journal of pathology · 2008
    3. BMP2 And BMP7 Play Antagonistic Roles In Feather Induction Development · 2008
    4. Identification of Dkk4 as a Target of Eda-A1/Edar Pathway Reveals an Unexpected Role of Ectodysplasin as Inhibitor of Wnt Signaling in Ectodermal Placodes Developmental biology · 2008
    5. Neuregulin3 Alters Cell Fate in the Epidermis and Mammary Gland BMC developmental biology · 2007
    6. The Wnt Inhibitor, Dickkopf 4, Is Induced by Canonical Wnt Signaling During Ectodermal Appendage Morphogenesis Developmental biology · 2007
    7. Genetic Basis of Skin Appendage Development Seminars in cell & developmental biology · 2007
    8. Molecular Signaling in Feather Morphogenesis Current opinion in cell biology · 2006
    9. Hairless Triggers Reactivation of Hair Growth by Promoting Wnt Signaling Proceedings of the National Academy of Sciences of the United States of America · 2005
    10. Exploiting the Keratin 17 Gene Promoter to Visualize Live Cells in Epithelial Appendages of Mice Molecular and Cellular Biology · 2005
    11. Canonical WNT Signaling Promotes Mammary Placode Development and Is Essential for Initiation of Mammary Gland Morphogenesis Development · 2004
    12. Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors Development · 2004
    13. Morpho-Regulation of Ectodermal Organs ˜The œAmerican journal of pathology · 2004
    14. Integument Pattern Formation Involves Genetic and Epigenetic Controls: Feather Arrays Simulated by Digital Hormone Models ˜The œInternational journal of developmental biology · 2004
    15. Identification of a Secreted BMP Antagonist, Ectodin, Integrating BMP, FGF, and SHH Signals from the Tooth Enamel Knot Developmental biology · 2003
    16. Stimulation of Ectodermal Organ Development by Ectodysplasin-A1 Developmental Biology · 2003
    17. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999
    18. Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages During Skin Development The Journal of Cell Biology · 1998