Smart Bacteriophage Release from Bovine β-Lactoglobulin Fibrils-Based Hydrogel with Anti-MRSA, Biofilm Degradation, and Hair Follicle Regeneration Functions for Infected Burn Wounds

The study presents a novel approach for treating burn wounds infected with antibiotic-resistant bacteria using a pH-responsive hydrogel made from bovine β-lactoglobulin fibrils (BLGFs) and ODEX, which releases MRSA phages in response to bacterial growth. The MRSA phage, isolated from hospital sewage, showed excellent specificity and biofilm-degrading ability. The hydrogel not only effectively kills bacteria but also promotes wound healing by accelerating collagen deposition, hair follicle regeneration, and enhancing neovascularization. This strategy offers a promising alternative to traditional antibiotics, addressing the challenge of multidrug-resistant bacterial infections in burn wounds.