Efficacy and Tolerability of Scalp Cooling in Preventing Alopecia During (Neo)Adjuvant Chemotherapy for Breast Cancer

    June 2026 in “ Pathology & Oncology Research ”
    Dóra Sántha, Ágnes Dobi, Máté Iványi … Alíz Nikolényi
    Studysummary In this study, the Orbis PAXMAN® scalp cooling system showed effectiveness and good tolerability in preventing chemotherapy-induced hair loss in breast cancer patients, particularly those receiving anthracycline-free chemotherapy, though the presence of comorbidities was linked to a higher risk of severe alopecia.
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    Research cited in this study 9

    1. Systematic Review and Meta-Analysis of the Association Between Metabolic Syndrome and Androgenetic Alopecia Acta dermato-venereologica · 2021
    2. Psychological Aspects of Hair Disorders: Considerations for Dermatologists, Cosmetologists, Aesthetic, and Plastic Surgeons Skin appendage disorders · 2021
    3. Scalp Cooling to Prevent Chemotherapy-Induced Alopecia Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia · 2020
    4. Chemotherapy-Induced Alopecia Management: Clinical Experience and Practical Advice Journal of Cosmetic Dermatology · 2017
    5. The Influence of Various Parameters on the Success of Sensor-Controlled Scalp Cooling in Preventing Chemotherapy-Induced Alopecia Oncology Research and Treatment · 2015
    6. Permanent Scalp Alopecia Related to Breast Cancer Chemotherapy by Sequential Fluorouracil/Epirubicin/Cyclophosphamide (FEC) and Docetaxel: A Prospective Study of 20 Patients Annals of Oncology · 2012
    7. Chemotherapy-Induced Alopecia: Emotional Distress and Mitigation Strategies Seminars in Cutaneous Medicine and Surgery · 2009
    8. Androgens and Hair Growth Dermatologic Therapy · 2008
    9. Androgenetic Alopecia and Microinflammation International Journal of Dermatology · 2000