Regulation of Hair Follicle Cycle
January 2014
in “
PubMed
”
hair follicle cycle telogen anagen catagen follicular keratinocytes epithelial remodeling dermal remodeling sex hormones neurotrophins fibroblast growth factor transforming growth factor bone morphogenetic proteins vascular endothelial growth factor Sonic Hedgehog signaling pathways hair growth cycle growth phase resting phase regression phase keratinocyte proliferation hormones growth factors VEGF FGF TGF BMP
TLDR Hair growth is controlled by cycles influenced by hormones and various signals.
This review focused on the regulation of hair growth, highlighting the cyclic transformation of hair follicles through the resting (telogen), growth (anagen), and regression (catagen) phases. The anagen phase involved rapid proliferation of follicular keratinocytes, leading to hair shaft elongation and thickening. The cyclic changes required rapid remodeling of epithelial and dermal components and were controlled by various factors, including sex hormones, neurotrophins, FGF, TGF, BMP, VEGF, Sonic Hedgehog, and other signaling pathways.
