Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55α, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development

June 2020 in “ Frontiers in Cell and Developmental Biology ”

Nikita Panicker, Melody Coutman, Charley Lawlor-O’Neill, Richard Kahl, Séverine Roselli, Nicole M. Verrills

Studysummary This study found that the PP2A-B55α regulatory subunit is crucial for ectodermal development in mice, with knockout embryos displaying severe neural and epidermal defects and failing to survive to birth.

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