Pathogenesis of Cardiovascular Alterations in Dogs Treated with Minoxidil

    January 1989 in “ Toxicologic Pathology ”
    G. M. Mesfin, R. D. Piper, Donald W. DuCharme … Gerald R. Zins
    Studysummary This paper discusses the pathogenesis of cardiovascular lesions in dogs associated with minoxidil, noting that lesions were not prevented by adrenergic blockade or neural activity suppression, and highlights the differences in injury progression between coronary arteries and the right atrium.
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    Research cited in this study 9

    1. Review of Cardiovascular Findings in Humans Treated with Minoxidil Toxicologic Pathology · 1989
    2. Whole Body and Regional Hemodynamic Effects of Minoxidil in the Conscious Dog Journal of Cardiovascular Pharmacology · 1984
    3. Cardiac Morphologic Alterations in Acute Minoxidil Cardiotoxicity in Miniature Swine Experimental and Molecular Pathology · 1984
    4. Minoxidil: A Review of Its Pharmacological Properties and Therapeutic Use Drugs · 1981
    5. Minoxidil and Pericardial Effusion: An Idiosyncratic Reaction Clinical Pharmacology & Therapeutics · 1981
    6. Minoxidil: Right Atrial Cardiac Pathology in Animals and Humans Circulation · 1980
    7. Acute Cardiomyopathy Induced by the Vasodilating Antihypertensive Agent Minoxidil Toxicology and Applied Pharmacology · 1979
    8. Toxicological Studies with the Hypotensive Agent Minoxidil Toxicology and Applied Pharmacology · 1977
    9. Minoxidil: An Alternative to Nephrectomy for Refractory Hypertension The New England Journal of Medicine · 1973