Trypanocidal Effect of Isotretinoin Through the Inhibition of Polyamine and Amino Acid Transporters in Trypanosoma Cruzi

    March 2017 in “ PLoS neglected tropical diseases ”
    Chantal Reigada, Edward A. Valera-Vera, Melisa Sayé … Claudio A. Pereira
    Studysummary This study found that isotretinoin, a drug commonly used for acne, inhibits polyamine transport in Trypanosoma cruzi, leading to trypanocidal effects, and suggests its potential as a treatment for Chagas disease without affecting mammalian cell viability.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on journals.plos.org →
    Discuss this study in the Community →

    Research cited in this study 1

    1. Apoptosis May Explain the Pharmacological Mode of Action and Adverse Effects of Isotretinoin, Including Teratogenicity Acta dermato-venereologica · 2017