Unlocking Finasteride's Potential Via Carboxymethyl-Beta-Cyclodextrin Inclusion Complex For Androgenic Alopecia

    Reza Allahyari, Behnam Mahdavi, Esmail Rezaei‐Seresht, Mehdi Baghayeri
    Studysummary In this study, researchers developed a carboxylated β-cyclodextrin formulation to enhance finasteride's physicochemical properties, achieving an encapsulation efficiency of about 85% and indicating potential for controlled drug release in therapeutic applications. Their findings suggest this inclusion complex could improve delivery of hydrophobic drugs like finasteride.
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    Research cited in this study 11

    1. Topical Finasteride Dose Evaluation for Treatment of Androgenetic Alopecia Using Computer Simulations Annales pharmaceutiques françaises · 2021
    2. Physicochemical Characterization of Finasteride Nanosystem for Enhanced Topical Delivery International Journal of Nanomedicine · 2021
    3. Encapsulation of Finasteride with Native and Modified Gamma-Cyclodextrins: Extensive Characterization of the Complexes International Journal of Pharmaceutics · 2020
    4. Enhancement of Dermal Delivery of Finasteride Using Microemulsion Systems Advanced Pharmaceutical Bulletin · 2019
    5. Applications of Steroid Drugs Entrapped in Cyclodextrins Environmental Chemistry Letters · 2019
    6. Experimental, Molecular Docking Investigations and Bioavailability Study on the Inclusion Complexes of Finasteride and Cyclodextrins Drug Design Development and Therapy · 2017
    7. Androgenetic Alopecia: A Review Endocrine · 2017
    8. Preparation and Evaluation of a Multimodal Minoxidil Microemulsion Versus Minoxidil Alone in the Treatment of Androgenic Alopecia of Mixed Etiology: A Pilot Study Drug Design Development and Therapy · 2013
    9. Binary and Ternary Inclusion Complexes of Finasteride in HPβCD and Polymers: Preparation and Characterization Bioorganic & Medicinal Chemistry · 2009
    10. Androgen Dependence of Hirsutism, Acne, and Alopecia in Women Medicine · 2009
    11. Finasteride Drugs · 1993

    Related research 1

    1. Use of Finasteride in the Treatment of Men With Androgenetic Alopecia Journal of Investigative Dermatology Symposium Proceedings · 2003