Active Mitochondria In Healthy Spiny Mouse Fibroblasts Resemble Megamitochondria And Remain Resilient Across Lifespan

    October 2025
    Ebenezer NA Aryee, Ajoy Aloysius, Sandeep Saxena … Ashley W. Seifert
    Studysummary This study found that fibroblasts from highly regenerative mammals, such as spiny mice and rabbits, exhibit unique metabolic characteristics, including a preference for glycolysis and specific mitochondrial features, which may contribute to their resistance to oxidative stress and support tissue regeneration.
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    Research cited in this study 8

    1. Spiny Mice (Acomys) Have Evolved Cellular Features to Support Regenerative Healing Annals of the New York Academy of Sciences · 2025
    2. An ERK-Dependent Molecular Switch Antagonizes Fibrosis and Promotes Regeneration in Spiny Mice Science Advances · 2023
    3. Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts During Wound Healing Cell stem cell · 2020
    4. Fibroblasts and Wound Healing: An Update Regenerative Medicine · 2018
    5. The Blastema and Epimorphic Regeneration in Mammals Developmental Biology · 2017
    6. Inhibition of β-Catenin Signaling in Dermal Fibroblasts Enhances Hair Follicle Regeneration During Wound Healing Development · 2016
    7. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    8. Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys) Nature · 2012