Preparation of highly-concentrated autologous platelet-rich plasma for biomedical use

    April 2019 in “ The Ukrainian Biochemical Journal ”
    Volodymyr Chernyshenko, K. Shteinberg, G. G. Lugovska, M. V. Ryzhykova, T. M. Platonova, Daria Korolova, E. V. Lugovskoy
    The study developed a simple and effective method for preparing highly-concentrated autologous platelet-rich plasma (PRP) with a concentration of over 1∙10^6 1/µl from fresh blood of 5 healthy donors. By optimizing heparin concentrations to 5 U/ml, the researchers minimized clotting and maintained platelet reactivity, achieving a 54 ± 7% aggregation rate upon activation with adenosine diphosphate (ADP). The method ensured that less than 20% of platelets had altered shape and granularity, indicating their ability to release growth factors and other biologically active compounds. This preparation minimized hemorrhage risks at injection sites, supporting its use in cell therapy for wound healing and tissue regeneration.
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      community Thoughts on platelet-rich plasma therapy

      in Treatment  3 upvotes 1 year ago
      Platelet-rich plasma (PRP) therapy for hair loss is expensive, painful, and often ineffective, with mixed reviews on its benefits. Alternatives like minoxidil, finasteride, and hair transplants are suggested as more reliable options.

      community Platelet rich plasma treatment

      in Treatment  6 upvotes 1 year ago
      A 27-year-old male experienced rapid hair loss after dengue fever, which activated a balding gene. The doctor suggested platelet-rich plasma treatment for hair regrowth.

      community platelet rich plasma experiences/thoughts?

      in Treatment  3 upvotes 3 years ago
      Hair loss discussion includes treatments like Minoxidil, finasteride, and RU58841. Platelet rich plasma treatment is considered expensive but cheaper than hair transplant.

      community PRP ( PLATELET-RICH-PlASMA) for hair loss

      in Treatment  1 upvotes 2 years ago
      A 27-year-old male experiencing hair loss post-Covid is considering PRP (platelet-rich plasma) therapy. He's seeking personal experiences about the process, particularly regarding pain levels, despite his dermatologist's assurance of using local anesthesia.

      community Do Platelet-rich plasma, PRP work?

      in Research/Science  14 upvotes 2 years ago
      Someone's brother tried Platelet-rich plasma (PRP) for hair loss; it had minimal effect on hair but improved skin appearance. Microneedling at home was suggested as a more sustainable alternative.

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