Faculty Opinions Recommendation of Hair Follicle Stem Cell-Specific PPARgamma Deletion Causes Scarring Alopecia

    May 2009 in “ Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ”
    Manabu Ohyama
    TLDR PPARgamma is crucial for healthy hair follicles, and its loss causes scarring alopecia.
    The study by Karnik et al. explored the role of peroxisome proliferator-activated receptor gamma (PPARg) in the pathogenesis of lichen planopilaris (LPP), a form of primary scarring alopecia. The researchers found that genes involved in lipid metabolism and peroxisome biogenesis were downregulated in LPP lesions. They demonstrated that PPARg was also downregulated in LPP-affected skin, and that PPARg agonists could enhance gene expression related to peroxisomal and lipid metabolism in human keratinocytes. Furthermore, the targeted deletion of PPARg in hair follicle-bulge stem cells in mice resulted in a phenotype similar to scarring alopecia, suggesting a link between decreased PPARg and hair loss disorders. The study proposed that restoring PPARg function could be a potential treatment strategy for LPP and similar hair loss conditions.
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      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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      in Research/Science  56 upvotes 8 months ago
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      community Hair Loss & Lipids: Why you have sebderm, folliculitis, LPP, inflammation, etc...

      in Research/Science  132 upvotes 8 months ago
      Excess sebum rich in cholesterol and triglycerides can lead to hair loss through inflammation, with treatments like Ciclopirox shampoo, Benzoyl Peroxide shampoo, and Clindamycin gel recommended for managing conditions like seborrheic dermatitis and folliculitis. Pioglitazone is suggested for Lichen Planopilaris, while Omega-3s and reducing processed foods may improve sebum quality, though genetic factors play a significant role.

      community The Worst Hair Loss Condition You (MAY) have: LPP

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