Polygenic Risk Score Predicting Susceptibility and Outcome of Benign Prostatic Hyperplasia in the Han Chinese

    May 2024 in “ Human Genomics ”
    Sheng-Chun Hung, Li‐Wen Chang, Tzu‐Hung Hsiao … I‐Chieh Chen
    Studysummary Among a Han Chinese cohort, this study found that a higher genetic risk score was linked to increased susceptibility to BPH, larger prostate size, reduced effectiveness of 5ARI treatment, and a higher risk of undergoing TURP.
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    Research cited in this study 5

    1. Consequences of Steroid-5α-Reductase Deficiency and Inhibition in Vertebrates General and Comparative Endocrinology · 2020
    2. Androgenetic Alopecia and Polymorphism of the Androgen Receptor Gene (SNP rs6152) in Patients with Benign Prostate Hyperplasia or Prostate Cancer Journal of The European Academy of Dermatology and Venereology · 2014
    3. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011
    4. 5alpha-Reductase: History and Clinical Importance PubMed · 2004
    5. The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia The New England Journal of Medicine · 2003