Subcutaneous Injection of Conditioned Medium From Photobiomodulation-Treated Adipose-Derived Stromal Cells Promotes Hair Growth and Angiogenesis in Mice
June 2025
in “
Archives of Dermatological Research
”
conditioned medium photobiomodulation adipose-derived stromal cells hair growth angiogenesis light-emitting diode growth factors VEGF EGF HGF IGF PDGF IGFBP alopecia LED vascular endothelial growth factor epidermal growth factor hepatocyte growth factor insulin-like growth factor platelet-derived growth factor insulin-like growth factor binding protein
TLDR Light-treated cell medium boosts hair growth in mice.
This study investigated the effects of subcutaneous injection of conditioned medium (CM) from photobiomodulation (PBM)-treated adipose-derived stromal cells (ASCs) on hair growth in mice. Human ASCs were exposed to light-emitting diode (660 nm, 50 mW/cm2) for 10 minutes daily over 10 days, and the resulting PBM-CM was analyzed for growth factors. The study found that PBM-CM significantly increased the secretion of growth factors such as VEGF, EGF, HGF, IGF, PDGF, and IGFBP, which are associated with hair growth and angiogenesis. In a hair loss model, PBM-CM enhanced hair regrowth compared to non-irradiated ASC-CM or PBS, suggesting that PBM is an effective biostimulator for hair regrowth and has potential as a treatment for alopecia.
