Subcutaneous Injection of Conditioned Medium From Photobiomodulation-Treated Adipose-Derived Stromal Cells Promotes Hair Growth and Angiogenesis in Mice

June 2025 in “ Archives of Dermatological Research ”

In‐Su Park

TLDR Light-treated cell medium boosts hair growth in mice.

This study investigated the effects of subcutaneous injection of conditioned medium (CM) from photobiomodulation (PBM)-treated adipose-derived stromal cells (ASCs) on hair growth in mice. Human ASCs were exposed to light-emitting diode (660 nm, 50 mW/cm2) for 10 minutes daily over 10 days, and the resulting PBM-CM was analyzed for growth factors. The study found that PBM-CM significantly increased the secretion of growth factors such as VEGF, EGF, HGF, IGF, PDGF, and IGFBP, which are associated with hair growth and angiogenesis. In a hair loss model, PBM-CM enhanced hair regrowth compared to non-irradiated ASC-CM or PBS, suggesting that PBM is an effective biostimulator for hair regrowth and has potential as a treatment for alopecia.

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Research cited in this study

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