Ovine KRT81 Variants and Their Influence on Selected Wool Traits of Commercial Value

    May 2024 in “ Genes
    Wenhao Li, Lingrong Bai, Huitong Zhou, Zhihe Zhang, Zhijie Ma, Guofang Wu, Yuzhu Luo, Jasmine Tanner, Jon G. H. Hickford
    This study investigated the influence of genetic variations in the 5′ untranslated region of the sheep keratin gene KRT81 on wool traits in 389 Merino × Southdown cross sheep. Three sequence variants (A, B, and C) were identified, with variant B linked to a reduction in clean fleece weight and variant C associated with an increase in both greasy and clean fleece weight. No effects were observed on staple length or mean-fibre-diameter-related traits. The findings suggest that KRT81 variations may affect wool growth by altering wool follicle density or the skin area producing fibre, rather than affecting fibre extrusion rate or diameter.
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