Phase-Specific Differential Regulation of Mechanical Allodynia in a Murine Model of Neuropathic Pain by Progesterone

    December 2023 in “ Frontiers in pharmacology ”
    Sheu Ran Choi, Dae Hyun Roh, Ji‐Young Moon … Jang Hern Lee
    Studysummary In this study, intrathecal progesterone administration initially worsened mechanical allodynia in mice after nerve injury, but later reduced pain when applied during the maintenance phase, highlighting distinct roles for cytochrome P450c17 and 5α-reductase in neuropathic pain modulation.
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    Research cited in this study 1

    1. Neuroactive Steroids Inhibit Spinal Reflex Potentiation by Selectively Enhancing Specific Spinal GABAA Receptor Subtypes Pain · 2009