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research Phase-specific differential regulation of mechanical allodynia in a murine model of neuropathic pain by progesterone

December 2023 in “Frontiers in pharmacology”

In this study, intrathecal progesterone administration initially worsened mechanical allodynia in mice after nerve injury, but later reduced pain when applied during the maintenance phase, highlighting distinct roles for cytochrome P450c17 and 5α-reductase in neuropathic pain modulation.

research Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and δ-Subunit-Containing Gamma-Aminobutyric Acid A Receptors

16 citations , November 2018 in “The journal of pain/Journal of pain”

This study found that in a rat model, 14,15-EET may alleviate central poststroke pain by enhancing thalamic inhibition through neurosteroid signaling, potentially outperforming gabapentin in early-stage treatment.

research Chemogenetic inhibition of Grpr- and/or Npff- expressing spinal neurons in mice suppresses chloroquine-evoked itch, but not signs of mechanical allodynia in a neuropathic pain model

April 2026 in “ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)”

research Minoxidil is a potential neuroprotective drug for paclitaxel-induced peripheral neuropathy

28 citations , March 2017 in “Scientific Reports”

This study found that minoxidil may protect against chemotherapy-induced peripheral neuropathy and potentially support hair recovery and tumor suppression in mouse models.

research Analgesic Effect of Human Placenta Hydrolysate on CFA-Induced Inflammatory Pain in Mice

2 citations , September 2024 in “Pharmaceuticals”

This study suggests that human placenta hydrolysate reduces CFA-induced inflammatory pain in mice by inhibiting pro-inflammatory cytokines and protecting peripheral nerves.

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community Hair loss research focused on chemistry for decades because we misunderstood the mechanics of growth.

51 upvotes 7 months ago

Hair growth relies on mechanical forces, not just chemicals, with tissue acting like a motor. Minoxidil and finasteride help, but maintaining tissue elasticity and addressing mechanical issues are essential.

community How to deal with mechanically induced shedding

4 upvotes 11 months ago

Minoxidil can cause scalp dryness and flaking, leading to hair shedding when exfoliating. Alternatives like oral Minoxidil, finasteride, and ketoconazole shampoo are suggested to manage these issues.

community Funny Encounter With a Mechanic - Hair Loss Update

in Update 39 upvotes 5 months ago

The user has been taking 3.75mg of finasteride weekly for 8 months, which has improved their hairline and hair texture. They shared a humorous encounter with a bald mechanic who complimented their hair, unaware of the finasteride use.

community Hi-c5 protein, explains why the mechanical tension theory may be correct.

22 upvotes 1 month ago

Hair loss may be influenced by mechanical tension and inflammation, with the hi-c5 protein amplifying androgen effects, leading to follicle miniaturization. Treatments like finasteride, minoxidil, and scalp massages are suggested to manage hair loss.

community Finally jumped on Fin after decent regrowth using all natural regime (mechanical stimulation)

5 upvotes 8 years ago

The user experienced good hair regrowth using natural methods and mechanical stimulation but decided to add finasteride to their regimen for better results. They are optimistic about further regrowth and plan to update on the effects of finasteride, noting no significant side effects so far.

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