research Possible Involvement of 5α-Reduced Neurosteroids in Adrenergic and Serotonergic Stimulation of GFAP Gene Expression in Rat C6 Glioma Cells
5α-reduced neurosteroids may help regulate glial cell differentiation.
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research Beta-Catenin Signaling Increases in Proliferating NG2+ Progenitors and Astrocytes During Post-Traumatic Gliogenesis in the Adult Brain
β-Catenin signaling is involved in brain cell growth after injury and could be a therapy target.
research Treatment of Male Rats with Finasteride, an Inhibitor of 5alpha-Reductase Enzyme, Induces Long-Lasting Effects on Depressive-Like Behavior, Hippocampal Neurogenesis, Neuroinflammation, and Gut Microbiota Composition
Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.
research Histone Deacetylase Inhibitors Promote Neurosteroid-Mediated Cell Differentiation and Enhance Serotonin-Stimulated Brain-Derived Neurotrophic Factor Gene Expression in Rat C6 Glioma Cells
HDAC inhibitors help brain cells grow and improve brain function.
research Development of Gene Therapy for Inner Ear Disease: Using Bilateral Vestibular Hypofunction as a Vehicle for Translational Research
Gene therapy, especially using atoh1, shows promise for creating functional sensory hair cells in the inner ear, but dosing and side effects need to be managed for clinical application.
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