Establishment and Characterization of a Canine Keratinocyte Organoid Culture System

July 2018 in “ Veterinary Dermatology ”

Dominique J. Wiener, Onur Basak, Priyanca Asra, Kim E. Boonekamp, Kai Kretzschmar, Angelos Papaspyropoulos, Hans Clevers

canine keratinocyte organoids interfollicular epidermis hair follicles keratins 5 keratins 14 HF stem cell markers growth factors dermal papilla

Studysummary This study established a 3D in vitro culture system of canine keratinocyte organoids to study epidermal function and address skin disorders in dogs, though additional growth factors are needed for hair follicle development.

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research An Overview of Alopecias

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research Epidermal Structure Created by Canine Hair Follicle Keratinocytes Enriched with Bulge Cells in a Three-Dimensional Skin Equivalent Model In Vitro: Implications for Regenerative Therapy of Canine Epidermis

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Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells