Identification of Novel Hair-Growth Inducers by Means of Connectivity Mapping

    December 2009 in “ The FASEB Journal ”
    Yumiko Ishimatsu‐Tsuji, Tsutomu Soma, Jiro Kishimoto
    TLDR Fluphenazine and iloprost can induce hair growth.
    The study aimed to identify new hair-growth inducers using connectivity mapping (Cmap) and gene expression profiling. Researchers analyzed gene expression in mice treated with cyclosporin A (CsA), a known hair-growth inducer, and identified several agents with similar gene signatures. Fluphenazine, identified from the day 2 signature, successfully induced hair growth in vivo, and its effect was enhanced by subsequent application of iloprost, identified from the day 4 signature. The study demonstrated that Cmap analysis was effective in linking gene expression profiles to potential hair-growth agents, suggesting a promising method for discovering treatments for hair cycle disorders.
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