New Small Molecules in Dermatology: For Autoimmunity, Inflammation, and Beyond

The review discusses the development of new small molecule drugs in dermatology, focusing on their ability to block specific intracellular signaling pathways involved in autoimmune and inflammatory diseases. It highlights the role of protein kinases such as JAK, Src, Syk, MAPK, and BTK in these processes. These small molecules are effective in treating conditions like psoriasis, alopecia areata, and vitiligo, offering new hope for patients with complex skin diseases. JAK inhibitors, in particular, are explored for their potential in managing skin disorders, though they carry risks such as infections and potential malignancies. The review underscores the need for further investigation into the long-term safety and efficacy of these treatments.