Needle-Free Jet Delivery of Minoxidil in Early Female Pattern Hair Loss: An Observational Comparative Study in Asian Women

    July 2026 in “ European Journal of Plastic Surgery ”
    Kyu‐Ho Yi, Yerin Park, Isaac Kai Jie Wong … Lee Kyu-Eun
    Studysummary This study found that combining needle-free intradermal minoxidil delivery with standard topical minoxidil therapy improved early hair growth parameters and satisfaction in women with early-stage female pattern hair loss compared to topical therapy alone, with no serious adverse events reported over the 10-week period.
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    Research cited in this study 12

    1. Optimizing Efficacy: Hyaluronic Acid Liposomes Encapsulating Minoxidil for Enhanced Transdermal Delivery and Treatment of Androgenetic Alopecia Colloids and Surfaces B Biointerfaces · 2025
    2. Key Considerations of Injectable Minoxidil for Alopecia Archives of Dermatological Research · 2025
    3. Evaluating the Efficacy and Safety of Combined Microneedling Therapy Versus Topical Minoxidil in Androgenetic Alopecia: A Systematic Review and Meta-Analysis Archives of Dermatological Research · 2025
    4. Efficacy and Safety of Combinational Therapy Using Topical Minoxidil and Microneedling for the Treatment of Androgenetic Alopecia: A Systematic Review and Meta-Analysis Archives of Dermatological Research · 2023
    5. Injections of Platelet-Rich Plasma Prepared by Automatic Blood Cell Separator Combined With Topical 5% Minoxidil in the Treatment of Male Androgenetic Alopecia Skin Research and Technology · 2023
    6. Unexpected Refractory Hypotension Following Intradermal Minoxidil Injection Clinical Toxicology · 2023
    7. Minoxidil-Loaded Hyaluronic Acid Dissolving Microneedles to Alleviate Hair Loss in an Alopecia Animal Model Acta Biomaterialia · 2022
    8. Quality of Life in Young Men with Androgenetic Alopecia: A Mixed Methods Study Journal of Cosmetic Dermatology · 2021
    9. Male and Female Pattern Hair Loss: Treatable and Worth Treating Cleveland Clinic Journal of Medicine · 2021
    10. Intradermal Injections With 0.5% Minoxidil for the Treatment of Female Androgenetic Alopecia: A Randomized, Placebo-Controlled Trial Dermatologic Therapy · 2020
    11. Efficacy of Intradermal Minoxidil 5% Injections for Treatment of Patchy Non-Severe Alopecia Areata Journal of Dermatological Treatment · 2020
    12. Hair Loss Perception and Symptoms of Depression in Female Outpatients Attending a General Dermatology Clinic Anais Brasileiros de Dermatologia · 2012