Keloid Pathogenesis and Fibroproliferative Properties Are Dependent on Stem Cells Regulated by the Hedgehog-Gli1 Pathway

    May 2023 in “ Research Square (Research Square) ”
    Mamiko Tosa, Yoshinori Abe, Seiko Egawa, Takuya Hatakeyama, Chihiro Iwaguro, Ryotaro Mitsugi, Ayaka Morishita, Tsuyoshi Sano, Rei Ogawa, Nobuyuki Tanaka
    From the encyclopedia
    Osteopontin →

    signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

    collagen →
    Image

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study observed that the Hedgehog-GLI1 signaling pathway is upregulated in keloid patient–derived stem cells, and inhibiting this pathway reduced keloid characteristics in both mice and ex vivo tissue cultures, suggesting potential therapeutic targets for keloid treatment.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results