Microneedle-Mediated Hypoxic Extracellular Vesicle-Encapsulated Selenium Nanoparticles Delivery to Treat Androgenetic Alopecia

March 2025 in “ Journal of Controlled Release ”

Shuili Jing, Yonghao Liu, Ben Wang, Heng Zhou, Hui Zhang, Prakriti Siwakoti, Xiangyu Qu, Peng Ye, Yan He, Tushar Kumeria, Qingsong Ye

microneedle patches hypoxic extracellular vesicle selenium nanoparticles astragalus polysaccharide oxidative stress angiogenesis inflammation androgenetic alopecia hair follicle activation vascularization Minoxidil microneedle Se-HEVs AGA Rogaine

TLDR The new treatment using microneedle patches shows promise for better hair growth in androgenetic alopecia.

The study explores a new treatment for androgenetic alopecia (AGA) using microneedle patches to deliver hypoxic extracellular vesicle-encapsulated selenium nanoparticles (Se-HEVs) and astragalus polysaccharide. This approach targets oxidative stress, insufficient angiogenesis, and inflammation, which are key factors in AGA. In a study involving 36 male KM mice, the Se-HEVs-AMN patches demonstrated superior hair growth compared to Minoxidil, with increased hair follicle activation, reduced inflammation, and enhanced vascularization. The results suggest that this multidimensional strategy holds promising potential for promoting hair growth and treating AGA.

View this study on linkinghub.elsevier.com →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research A Combination Therapy for Androgenic Alopecia Based on Quercetin and Zinc/Copper Dual-Doped Mesoporous Silica Nanocomposite Microneedle Patch

1 citations, December 2022 in “Bioactive Materials”

The microneedle patch with quercetin, zinc, and copper effectively promotes hair regrowth for androgenic alopecia.

research Machine Learning Guided Discovery of Superoxide Dismutase Nanozymes for Androgenetic Alopecia

3 citations, October 2022 in “Nano Letters”

Machine learning identified promising nanozymes for treating hair loss.

research Conditioned Media-Integrated Microneedles for Hair Regeneration Through Perifollicular Angiogenesis

12 citations, August 2022 in “Journal of Controlled Release”

A new microneedle patch effectively promotes hair growth by increasing blood vessel formation around hair follicles.

research A Drug-Free, Hair Follicle Cycling Regulatable, Separable, Antibacterial Microneedle Patch for Hair Regeneration Therapy

31 citations, July 2022 in “Advanced healthcare materials/Advanced Healthcare Materials”

A drug-free microneedle patch significantly promotes hair growth and prevents infections.

research Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment

38 citations, July 2021 in “ACS Nano”

Microneedles help treat hair loss by improving hair surroundings and promoting growth.

research Functional Hair Follicle Regeneration: An Updated Review

42 citations, February 2021 in “Signal Transduction and Targeted Therapy”

Hair follicle regeneration possible, more research needed.

research Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration

59 citations, March 2020 in “Journal of Biomedical Science”

Understanding how hair follicle stem cells work can help find new ways to prevent hair loss and promote hair growth.

research Sustained Release of Dermal Papilla-Derived Extracellular Vesicles from Injectable Microgel Promotes Hair Growth

46 citations, January 2020 in “Theranostics”

Injecting a special gel with human protein particles can help hair grow.

Similar Research

5 / 627 results

research Tremella polysaccharide microneedles loaded with magnetic dental pulp stem cell intracellular vesicles used for androgenic alopecia

March 2025 in “Stem Cell Research & Therapy”

The study investigates a novel treatment for androgenic alopecia (AGA) using Tremella polysaccharide microneedles loaded with magnetic dental pulp stem cell intracellular vesicles (Mag-IVs). The microneedle system, which includes hyaluronic acid, aims to improve the hair follicle microenvironment by promoting angiogenesis, reducing inflammation, and protecting hair papillary cells from apoptosis. In vivo experiments on 42 male KM mice showed that this treatment significantly enhanced hair regeneration, with results comparable to Minoxidil. The findings suggest that this approach could offer a promising and minimally invasive alternative for AGA therapy, although further research is needed to address clinical translation challenges.

Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review

research Going Below and Beyond the Surface: Microneedle Structure, Materials, Drugs, Fabrication, and Applications for Wound Healing and Tissue Regeneration

61 citations, April 2023 in “Bioactive Materials”

Microneedles are effective for painless drug delivery and promoting wound healing and tissue regeneration.

Microneedle-Mediated Hypoxic Extracellular Vesicle-Encapsulated Selenium Nanoparticles Delivery to Treat Androgenetic Alopecia

Research cited in this study

research A Combination Therapy for Androgenic Alopecia Based on Quercetin and Zinc/Copper Dual-Doped Mesoporous Silica Nanocomposite Microneedle Patch

research Machine Learning Guided Discovery of Superoxide Dismutase Nanozymes for Androgenetic Alopecia

research Conditioned Media-Integrated Microneedles for Hair Regeneration Through Perifollicular Angiogenesis

research A Drug-Free, Hair Follicle Cycling Regulatable, Separable, Antibacterial Microneedle Patch for Hair Regeneration Therapy

research Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment

research Functional Hair Follicle Regeneration: An Updated Review

research Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration

research Sustained Release of Dermal Papilla-Derived Extracellular Vesicles from Injectable Microgel Promotes Hair Growth

Related Community Posts Join

community SCUBE3 Biannual Injections and Microneedling

community Hair repigmentation of poliosis circumscripta in androgenetic alopecia patient treated with exosomes and fractional picosecond laser

community 6 Month Progress (Sept 2021-Mar 2022) Fin,Min,Microneedling,Biotin, Ketoconazole Shampoo

community Essential Insights into Hair Loss: What You Should Know Early

community Boys I am just a gonner. What on earth is my scalp even going through. Looks like world war 3. Pyril 3 months. Topical melitonin/progesterone/fin, dut, fin, oral min, laser trash, anus stimulation. Nothing. Donor area is decimated 😂.

community 4 mont fin min and dermarolling

Similar Research

research Tremella polysaccharide microneedles loaded with magnetic dental pulp stem cell intracellular vesicles used for androgenic alopecia

research Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review

research Nanotechnology-Based Techniques for Hair Follicle Regeneration

research Cell Therapy for Androgenetic Alopecia: Elixir or Trick?

research Going Below and Beyond the Surface: Microneedle Structure, Materials, Drugs, Fabrication, and Applications for Wound Healing and Tissue Regeneration