Multi-Herbal Extracellular Vesicle and Growth Factor Serum for Eyelash Care: A Pilot Randomized, Double-Blind, Placebo-Controlled Clinical Study

    September 2026 in “ medRxiv ”
    Tsong-Min Chang, Chung-Chin Wu, Huey‐Chun Huang … Tzu‐Ting Kuo

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that a serum combining recombinant growth factors and plant-derived EVs significantly increased eyelash length and density without causing skin hyperpigmentation in healthy female participants over eight weeks.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 10

    1. Ginger-Derived Extracellular Vesicles: A Natural Solution for Alopecia Current Drug Delivery · 2024
    2. The Eyelash Follicle Features and Anomalies: A Review Journal of optometry · 2018
    3. Biology of the Eyelash Hair Follicle: An Enigma in Plain Sight British journal of dermatology/British journal of dermatology, Supplement · 2015
    4. Paracrine Crosstalk Between Human Hair Follicle Dermal Papilla Cells and Microvascular Endothelial Cells Experimental Dermatology · 2015
    5. Hypertrichosis and Hyperpigmentation in the Periocular Area Associated with Travoprost Treatment Annals of dermatology/Annals of Dermatology · 2015
    6. Effect of IGF-I on Hair Growth Is Related to the Anti-Apoptotic Effect of IGF-I and Up-Regulation of PDGF-A and PDGF-B Annals of Dermatology · 2012
    7. Enhancing the Growth of Natural Eyelashes: The Mechanism of Bimatoprost-Induced Eyelash Growth Dermatologic Surgery · 2010
    8. Bimatoprost in the Treatment of Eyelash Hypotrichosis Clinical ophthalmology · 2010
    9. Management of Hypotrichosis of the Eyelashes: Focus on Bimatoprost Clinical, cosmetic and investigational dermatology · 2010
    10. Human Hair Growth In Vitro: A Model for the Study of Hair Follicle Biology Journal of Dermatological Science · 1994