Morphogenesis of chimeric hair follicles in engineered skin substitutes with human keratinocytes and murine dermal papilla cells
August 2012
in “
Experimental Dermatology
”
Research cited in this study
9 / 9 results
research Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches
Regenerated fully functional hair follicles using stem cells, with potential for hair regrowth therapy.
research Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation
Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.
research Human TSC2-Null Fibroblast-Like Cells Induce Hair Follicle Neogenesis and Hamartoma Morphogenesis
Cells from a skin condition can create new hair follicles and similar growths in mice, and a specific treatment can reduce these effects.
research The Mesenchymal Component of Hair Follicle Neogenesis: Background, Methods, and Molecular Characterization
The document concludes that specific cells are essential for hair growth and more research is needed to understand how to maintain their hair-inducing properties.
research Activation of β-catenin signaling programs embryonic epidermis to hair follicle fate
The study demonstrated that activation of β-catenin signaling in adult mouse skin led to the formation of ectopic hair follicles, indicating that β-catenin plays a crucial role in hair follicle development. By inducing a stabilizing β-catenin mutation, researchers observed increased hair growth and the formation of new hair follicles in mutant mice compared to controls. The study used a genetic model involving Krt5-rtTA tetO-Cre Ctnnb1(Ex3)fl/+ mice treated with doxycycline, which resulted in densely packed, irregularly spaced hair follicles in an abnormal growth phase. The findings suggested that β-catenin signaling could reprogram epidermal cells to adopt a hair follicle fate, even in typically hairless regions like footpad skin.
research Order From Disorder: Self-Organization In Mammalian Hair Patterning
Hair patterns in mice are controlled by both a global system dependent on Fz6 and a local self-organizing system.
research Transient activation of β-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours
research Keratin 17 Expression in the Hard Epithelial Context of the Hair and Nail, and its Relevance for the Pachyonychia Congenita Phenotype
research The Secret Life of the Hair Follicle
Hair follicles create different cell layers and proteins, controlled by various molecules.
Related Research
7 / 7 results
research Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes
Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.
research A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles
Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.
research Review of Hair Follicle Dermal Cells
Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.
research Hair follicle reformation induced by dermal papilla cells from human scalp skin
research Study on Hair Follicle Formation Induced by Dermal Papilla Cells
Dermal papilla cells can help form hair follicles and produce hair.
research Trans-Species Hair Growth Induction by Human Hair Follicle Dermal Papillae
Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.
research Role of Hair Papilla Cells in Induction and Regeneration Processes of Hair Follicles
Hair papilla cells can create and regenerate hair bulbs under the right conditions.