Keratin 17 Expression in the Hard Epithelial Context of the Hair and Nail, and its Relevance for the Pachyonychia Congenita Phenotype
June 2000
in “
Journal of Investigative Dermatology
”
Research cited in this study
10 / 10 resultsresearch Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation
research The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16
K16 can partially replace K14 but causes hair loss and skin issues.
research Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages during Skin Development
research Keratin 17 Gene Expression during the Murine Hair Cycle
research Mutation of a type II keratin gene (K6a) in pachyonychia congenita
research Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin.
research Regulation of Keratin Gene Expression in Hair Follicle Differentiationa
research Keratins of the human hair follicle: “Hyperproliferative” keratins consistently expressed in outer root sheath cells in vivo and in vitro
research Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins
Hair and nail cells share similar proteins, indicating a common differentiation pathway.
research The complement of native α-keratin polypeptides of hair-forming cells: A subset of eight polypeptides that differ from epithelial cytokeratins
Related Research
9 / 9 resultsresearch Expression Patterns of Hair-Related Keratins and Epithelial Keratins in Onychopapilloma: The Significance of Clarifying the Origin of Onychopapilloma
Onychopapilloma likely originates from the nail bed, not the nail matrix.
research Hair Follicle-Specific Keratins And Their Diseases
Only a few hair-specific keratins are linked to inherited hair disorders.
research Keratins of the Human Hair Follicle
research Hair Keratin Pattern in Human Hair Follicles Grown In Vitro
Human hair follicles grown in vitro maintain normal keratin patterns and structure.
research Induction of Hard Keratin Expression in Non-Nail-Matrical Keratinocytes by Nail-Matrical Fibroblasts through Epithelial-Mesenchymal Interactions
Nail-matrical fibroblasts can make non-nail cells produce hard keratin, useful for nail repair.