TLDR The combined treatment helps improve severe hair loss and reduces the need for other medications.
The study presents a case of a female in her late twenties with alopecia totalis treated with a combination of modified platelet-rich plasma (PRP) and intralesional triamcinolone acetonide (TrA). Initial treatments with prednisolone, azathioprine, and minoxidil showed temporary improvement, but hair loss recurred upon tapering steroids. Modified PRP, prepared by a double spin method and combined with TrA, was administered intradermally. After four sessions at four-week intervals, significant hair regrowth and increased density were observed, allowing for the tapering of systemic steroids. The study concludes that modified PRP with TrA is a promising treatment for alopecia totalis, promoting early regrowth and reducing the need for prolonged immunosuppressant use. However, larger studies with longer follow-ups are needed to confirm these benefits.
2 citations,
January 2021 in “Clinical dermatology review” Modified PRP therapy successfully treated severe alopecia unresponsive to traditional methods.
3 citations,
August 2020 in “PubMed” Platelet-rich plasma (PRP) is effective in treating various skin conditions and improving hair density, thickness, and patient satisfaction, with lower relapse rates for Alopecia Areata.
214 citations,
September 2015 in “Stem Cells Translational Medicine” Platelet-rich plasma injections significantly improved hair regrowth and thickness in patients with hair loss.
61 citations,
January 2015 in “Indian Journal of Plastic Surgery” Platelet-rich plasma treatment could potentially be an effective way to treat chronic alopecia areata with minimal side effects.
36 citations,
January 2010 in “International Journal of Trichology” Intralesional steroids can help regrow hair in some alopecia areata patients but have side effects.
July 2023 in “Clinical dermatology review” Intralesional triamcinolone acetonide is better than PRP for treating scalp alopecia areata, leading to faster and more complete hair regrowth.
January 2023 in “Dermatologic Therapy” Platelet-rich plasma therapy is a safe and effective treatment for alopecia areata.
99 citations,
July 2017 in “Clinical Reviews in Allergy & Immunology” New treatments for Alopecia Areata show promise but need to be more effective and affordable.
November 2022 in “Frontiers in Medicine” PRP shows promise for treating mild alopecia areata but needs more research for cicatricial alopecias.
205 citations,
April 2013 in “British Journal of Dermatology” Platelet-rich plasma treatment significantly increased hair regrowth and decreased discomfort in alopecia patients, making it a potentially better and safer treatment option.
23 citations,
October 2018 in “Expert Opinion on Drug Safety” Consider benefits and risks of new alopecia treatments for safety.
