Modified Platelet Rich Plasma Therapy for Alopecia Totalis

The study presents a case of a female in her late twenties with alopecia totalis treated with a combination of modified platelet-rich plasma (PRP) and intralesional triamcinolone acetonide (TrA). Initial treatments with prednisolone, azathioprine, and minoxidil showed temporary improvement, but hair loss recurred upon tapering steroids. Modified PRP, prepared by a double spin method and combined with TrA, was administered intradermally. After four sessions at four-week intervals, significant hair regrowth and increased density were observed, allowing for the tapering of systemic steroids. The study concludes that modified PRP with TrA is a promising treatment for alopecia totalis, promoting early regrowth and reducing the need for prolonged immunosuppressant use. However, larger studies with longer follow-ups are needed to confirm these benefits.