Constitutive Stat3 Activation Alters Behavior of Hair Follicle Stem and Progenitor Cell Populations

September 2013 in “ Molecular Carcinogenesis ”

Dharanija Rao, Everardo Macías, Steve Carbajal, Kaoru Kiguchi, John DiGiovanni

Stat3 keratinocyte hair follicle stem cells CD34 α6 integrin Lgr-6 Lrig-1 Sca-1 c-myc β-catenin EMT α6-integrin

Studysummary This study found that constitutively active Stat3 in transgenic mice led to reduced keratinocyte stem cell populations in hair follicles, altering stem/progenitor cell dynamics and homeostasis.

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Research cited in this study

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research Targeted Disruption of Stat3 Reveals a Major Role for Follicular Stem Cells in Skin Tumor Initiation

49 citations , October 2009 in “Cancer research”

This study found that disrupting Stat3 in keratinocyte stem cells of mice reduced skin tumor formation by approximately 80%, suggesting Stat3's role in tumor initiation survival mechanisms.

research Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis

503 citations , May 2009 in “Cell stem cell”

This study suggests that Lrig1-positive cells form a previously unknown reservoir of interfollicular epidermal stem cells in adult mouse skin, influencing epidermal proliferation and hair follicle development.

research Disruption of Smad4 in Mouse Epidermis Leads to Depletion of Follicle Stem Cells

43 citations , December 2008 in “Molecular biology of the cell”

This study found that disrupting Smad4 signaling in young mice led to overactivation of follicle stem cells, causing hyperplasia and depletion of the stem cell niche.

research Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells

835 citations , October 2008 in “Nature Genetics”

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

research Role of β-Catenin in Epidermal Stem Cell Expansion, Lineage Selection, and Cancer

61 citations , January 2008 in “Cold Spring Harbor Symposia on Quantitative Biology”

This review examines beta-catenin's role in stem cell renewal, lineage selection, and tumor formation in the epidermis and reports no new experimental findings.

research The Cell-Surface Marker MTS24 Identifies a Novel Population of Follicular Keratinocytes With Characteristics of Progenitor Cells

207 citations , July 2006 in “Development”

This study identified a novel MTS24-positive murine keratinocyte population with increased colony-forming ability, suggesting these cells may serve as a new reservoir of proliferative progenitor or stem cells in hair follicles.

research Defining the Impact of Beta-Catenin/Tcf Transactivation on Epithelial Stem Cells

384 citations , June 2005 in “Genes & development”

This study found that stabilized beta-catenin is crucial for activating stem cell transition from quiescence to proliferation in hair follicles by influencing gene expression within the stem cell niche.

research Deregulated Expression of c-Myc Depletes Epidermal Stem Cells

315 citations , June 2001 in “Nature Genetics”

research C-Myc Activation in Transgenic Mouse Epidermis Results in Mobilization of Stem Cells and Differentiation of Their Progeny

338 citations , April 2001 in “Current Biology”

This study found that transient activation of c-Myc in transgenic mice stimulates keratinocyte proliferation and sebocyte differentiation, affecting normal epidermal and hair follicle development.

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

1010 citations , August 2000 in “Cell”

In this study, researchers found that hair follicle stem cells in mice can generate both hair follicle and epidermis cells, highlighting their potential bipotency.