TLDR MicroRNAs could lead to new treatments for skin diseases, but more research is needed.
MicroRNAs (miRs) are non-coding RNA molecules that play a crucial role in regulating gene expression and are involved in various physiological processes. They are being explored as biomarkers and therapeutic targets for dermatological diseases such as psoriasis, skin wounds, systemic sclerosis, skin tumors, and systemic lupus erythematosus. MiRs influence skin pathophysiology through mechanisms like oxidative stress, inflammation, apoptosis, and angiogenesis. Understanding miRs and their regulatory targets is vital for advancing skin disease treatment. While miRs combined with new materials may offer innovative therapies, more research is needed to translate these findings into clinical applications.
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January 2023 in “International Journal of Biological Sciences” A specific pathway involving AR, miR-221, and IGF-1 plays a key role in causing common hair loss.
147 citations
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November 2020 in “International Journal of Molecular Sciences” Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.
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May 2015 in “Advanced drug delivery reviews” MicroRNAs could improve skin tissue engineering by regulating cells and changing the skin's bioactive environment.
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September 2022 in “Human genomics” Key genes and pathways involved in thyroid eye disease were identified, aiding potential treatment and diagnosis.
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June 2017 in “Methods” Researchers created a model to understand heart aging, highlighting the role of microRNAs and identifying key genes and pathways involved.
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July 2017 in “Clinical Science” MicroRNAs are important for skin health and could be targets for new skin disorder treatments.
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October 2015 in “Human Gene Therapy” The congress highlighted new gene therapy techniques and cell transplantation methods for treating diseases.
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June 2019 in “Journal of Investigative Dermatology” miR-21 increases skin aging by reducing SATB1, affecting skin cell function.