MicroRNAs in the skin: role in development, homoeostasis and regeneration

    July 2017 in “ Clinical Science
    Steven Horsburgh, Nicola Fullard, Mathilde Roger, Abbie Degnan, Stephen Todryk, Stefan Przyborski, Steven O’Reilly
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    TLDR MicroRNAs are important for skin health and could be targets for new skin disorder treatments.
    The 2017 document reviews the role of microRNAs (miRs) in skin development, homeostasis, and regeneration, and their potential as therapeutic targets for skin conditions. It explains that miRs are small non-coding RNAs that regulate gene expression and are involved in various skin processes. The review highlights specific miRs, such as miR-203, miR-205, and miR-125b, and their roles in keratinocyte differentiation, skin stem cell proliferation, and skin morphogenesis. It also discusses miRs' involvement in skin inflammation, regeneration, and chronic skin disorders like atopic dermatitis and psoriasis, with miR-146a and miR-155 being particularly notable. The document suggests that manipulating miR expression could lead to new treatments for skin disorders and improve wound healing, but emphasizes the need for further research to overcome challenges related to delivery and specificity. It concludes that miRs, once considered 'junk DNA', are now recognized as crucial for post-transcriptional gene regulation with significant implications for skin biology.
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