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GlossaryPost-Transcriptional Gene Silencing

cells inhibit gene expression after RNA is made

Post-Transcriptional Gene Silencing (PTGS) is a cellular process where the expression of specific genes is inhibited after the DNA has been transcribed into RNA. This is often achieved through mechanisms like RNA interference (RNAi), where small RNA molecules bind to the messenger RNA (mRNA) and prevent it from being translated into proteins. This process is crucial for regulating gene expression and maintaining cellular function.

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research MicroRNAs in the Skin: Role in Development, Homeostasis, and Regeneration

31 citations, July 2017 in “Clinical Science”

MicroRNAs are important for skin health and could be targets for new skin disorder treatments.

research Dicer- And BSC-Dependent miRNAs During Murine Anagen Development

1 citations, January 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Dicer is crucial for hair growth in mice.

research Epidermal Differentiation Complex: A Review on Its Epigenetic Regulation and Potential Drug Targets

39 citations, January 2016 in “PubMed”

Understanding how EDC genes are regulated can help develop better drugs for skin diseases.

research LncRNA-miRNA-mRNA Regulatory Networks in Skin Aging and Therapeutic Potentials

3 citations, October 2023 in “Frontiers in physiology”

ceRNA networks offer potential treatments for skin aging and wound healing.

research The Role of hsa-miR-193a-5p as an Important Factor for Control of Inositol in Alopecia Areata

June 2024 in “Skin Research and Technology”

hsa-miR-193a-5p may help diagnose and treat alopecia areata.

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community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 2 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community Fats on your Head to Stop Hair Loss?

in Research/Science 138 upvotes 9 months ago

The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Adrogens and Covid-19

in Treatment 8 upvotes 4 years ago

The possible increased risk of severe Covid-19 cases in men due to higher androgen levels, and how taking medications such as finasteride, dutasteride, spironolactone, enzalutamide, or canabidiol might help mitigate the severity of the disease.

community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 40 upvotes 1 year ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

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