Intra-Individual Comparative Study of Methotrexate Versus Triamcinolone Acetonide Delivered via Microneedling for Recalcitrant Alopecia Areata

    July 2026 in “ Dermatology Practical & Conceptual ”
    Mofreh Mansour, Refaat Mohamed, athar mohamed, Mahmoud A. Rageh
    Studysummary This study found that while both microneedling-assisted methotrexate and triamcinolone acetonide treatments led to improvements in recalcitrant alopecia areata, methotrexate-treated areas had significantly better outcomes in terms of SALT score reduction, patient satisfaction, and relapse rates, suggesting its superior short-term efficacy.
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    Research cited in this study 14

    1. A Three-Step Diagnostic Algorithm for Alopecia: Pattern Analysis in Trichoscopy Journal of Clinical Medicine · 2025
    2. Microneedling in Dermatology: A Comprehensive Review of Applications, Techniques, and Outcomes Cureus · 2024
    3. Trichoscopy Patterns in Alopecia Areata: A Systematic Review and Meta-Analysis Skin Research and Technology · 2023
    4. Microneedling With Triamcinolone Acetonide Versus Intralesional Triamcinolone Acetonide in Treatment of Alopecia Areata Al-Azhar International Medical Journal /Al-Azhar International Medical Journal · 2023
    5. Transepidermal Delivery of Triamcinolone Acetonide or Platelet Rich Plasma Using Either Fractional Carbon Dioxide Laser or Microneedling in Treatment of Alopecia Areata Dermatology practical & conceptual · 2022
    6. Comparative Efficacy of Injection Triamcinolone Acetonide Given Intralesionally and Through Microneedling in Alopecia Areata International Journal of Trichology · 2022
    7. Successful Response to a Combination of Intralesional Methotrexate and Fractional CO2 Laser in Refractory Alopecia Areata: Case Report Skin appendage disorders · 2022
    8. Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management Clinical Reviews in Allergy & Immunology · 2021
    9. Identification of Novel Step-Up Regimen of Intralesional Triamcinolone Acetonide in Scalp Alopecia Areata Based on a Double-Blind Randomized Controlled Trial Dermatologic Therapy · 2020
    10. Alopecia Areata: A Review of Disease Pathogenesis British journal of dermatology/British journal of dermatology, Supplement · 2018
    11. Alopecia Areata: Treatment Options and Efficacy Journal of the American Academy of Dermatology · 2017
    12. Low-Dose Systemic Methotrexate Therapy for Recalcitrant Alopecia Areata Annals of Dermatology · 2017
    13. Alopecia Areata: What’s New in Epidemiology, Pathogenesis, Diagnosis, and Therapeutic Options? Journal of dermatological science · 2016
    14. Alopecia Areata Update Journal of the American Academy of Dermatology · 2010