Investigation Into the Metabolism and Elimination Behavior of RU 58841 and Its Influence on the Steroid Profile in Humans

    August 2026 in “ Biomedical Chromatography ”
    Aylin Okutan, Oliver Krug, Gregor Fußhöller … Mario Thevis
    Studysummary This study found that topical application of RU 58841 resulted in considerable systemic exposure, identifying several metabolites without affecting steroid profile determinations in routine doping controls.
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    Research cited in this study 6

    1. Mesotherapy With Bicalutamide: A New Treatment for Androgenetic Alopecia International Journal of Trichology · 2023
    2. Bicalutamide: A Potential New Oral Antiandrogenic Drug for Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2020
    3. Androgenetic Alopecia: A Review Endocrine · 2017
    4. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998
    5. Evaluation of RU58841 as an Anti-Androgen in Prostate PC3 Cells and a Topical Anti-Alopecia Agent in the Bald Scalp of Stumptailed Macaques Endocrine · 1998
    6. RU 58841, A New Specific Topical Antiandrogen: A Candidate of Choice for the Treatment of Acne, Androgenetic Alopecia, and Hirsutism The Journal of Steroid Biochemistry and Molecular Biology · 1994