Managing Estrogen-Deficient Skin: A Narrative Review on the Role of Hormone Replacement Therapy and Emerging Estrogen-Modulating Therapies

December 2025 in “ International Journal of Innovative Technologies in Social Science ”

Wiktoria Januszkiewicz, Adam Januszkiewicz, Maria Gierasimiuk, Michal Gorski, Kamil Franczyk, K. Świerk, Damian Podkościelny, Wojciech Machulski, Martyna Ciarkowska, Jan Krzysztof Makulski

estrogen deficiency menopause collagen hormone replacement therapy HRT topical estrogen estrogen-modulating treatments transdermal HRT systemic therapy SERMs phytoestrogens estrogen systemic HRT topical treatments selective estrogen receptor modulators

Studysummary This review suggests that while estrogen-targeted therapies may improve skin quality in postmenopausal women, systemic risks limit hormone replacement therapies, and more research is needed for localized treatments.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on doi.org →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research Managing Menopausal Skin: A Clinician’s Review

1 citations , September 2025 in “EMJ Dermatology”

Menopause affects skin and hair, and more research is needed for effective treatments.

research Hormonal Therapies in Cosmetic Dermatology: Mechanisms, Clinical Applications, and Future Perspectives

2 citations , September 2025 in “Cosmetics”

This narrative review synthesized current research on hormonal therapies in cosmetic dermatology, finding they offer promising, evidence-based applications for conditions like aging skin, acne, and melasma, but noting that safety and personalized treatment approaches are essential for responsible clinical use.

research Managing Menopausal Skin Changes: A Narrative Review of Skin Quality Changes, Their Aesthetic Impact, and the Role of Hormone Replacement Therapy

4 citations , August 2025 in “Journal of Cosmetic Dermatology”

This study found that while hormone replacement therapy can improve skin aging in menopausal women, inconsistent findings and a lack of robust clinical trials mean it isn't recommended purely for skin benefits.

research Dermatological Changes During Menopause and HRT: What to Expect

January 2024 in “Cosmetics”

In this study, Brazilian postmenopausal women reported that menopause significantly deteriorates the quality of their skin, nails, and hair, negatively affecting self-esteem and quality of life, with a need for better understanding of hormone replacement therapy's dermatological effects.

research Menopause, Skin And Common Dermatoses. Part 2: Skin Disorders

25 citations , June 2022 in “Clinical and Experimental Dermatology”

This review discusses how menopause affects skin structure and function, finding associations between menopause and common skin conditions, but reports no new clinical results.

research Skin, Hair, and Beyond: The Impact of Menopause

14 citations , April 2022 in “Climacteric”

This review discusses the impact of HRT on menopausal skin and hair symptoms and argues that potential benefits should be part of informed decision-making for managing menopause.

research A Review of the Role of Estrogen in Dermal Aging and Facial Attractiveness in Women

58 citations , February 2018 in “Journal of cosmetic dermatology”

This review explores how estrogens influence skin health and attractiveness in women, particularly with aging, but it reports no new clinical findings.

research The Role Of Estrogen In Cutaneous Aging And Repair

158 citations , June 2017 in “Maturitas”

This review discusses the role of estrogen deficiency in post-menopausal skin aging and wound healing, highlighting opportunities for developing estrogen receptor-targeted therapies and reports no new clinical results.