DHT Deficiency Perturbs the Integrity of the Rat Seminiferous Epithelium by Disrupting Tight and Adherens Junctions

April 2011 in “ Folia Histochemica et Cytobiologica ”

Agnieszka Kolasa, Mariola Marchlewicz, L Wenda-Rózewicka, Barbara Wiszniewska

DHT finasteride seminiferous epithelium tight junctions adherens junctions N-cadherin β-catenin occludin vinculin hormonal imbalance dihydrotestosterone Propecia

Studysummary In this study using rats, finasteride-induced DHT deficiency led to morphological changes in seminiferous tubules, linked with altered junctional protein expression, potentially impairing fertility.

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research DHT Deficiency Perturbs the Integrity of the Rat Seminiferous Epithelium by Disrupting Tight and Adherens Junctions

27 citations , April 2011 in “Folia Histochemica et Cytobiologica”

In this study using rats, finasteride-induced DHT deficiency led to morphological changes in seminiferous tubules, linked with altered junctional protein expression, potentially impairing fertility.

research The Expression of Inducible Nitric Oxide Synthase (iNOS) in the Testis and Epididymis of Rats with a Dihydrotestosterone (DHT) Deficiency

28 citations , January 2009 in “Cellular & Molecular Biology Letters”

This study concluded that finasteride-induced DHT deficiency intensified constitutive iNOS expression in rat testicular and epididymal cells, suggesting a complex regulatory relationship needing further investigation.

research Expression of E-SOD, GPX5 mRNAs and Immunoexpression of Cu/ZnSOD in Epididymal Epithelial Cells of Finasteride-Treated Rats

10 citations , September 2008 in “Andrologia”

In this study, treatment with finasteride altered the expression patterns of antioxidant enzymes in the epididymis of rats, potentially affecting its protective function for spermatozoa.

research Actions of 5α-Reductase Inhibitors on the Epididymis

48 citations , February 2006 in “Molecular and Cellular Endocrinology”

This study found that dual 5α-reductase inhibitors in rats decreased sperm quality and led to reduced pregnancy success, suggesting potential for use in male contraception.

research Epididymis in an Experimental Model of DHT Deficiency: Immunolocalization of ERalpha and ERbeta in Rat Epididymal Epithelial Cells. In Vivo and In Vitro Studies

4 citations , January 2006 in “PubMed”

This study found that finasteride-induced DHT deficiency altered estrogen receptor expression in the epididymis, potentially destabilizing its function.