Low-Dose Oral Versus Topical Minoxidil in Androgenetic Alopecia: A Randomized, Double-Blind, Double-Dummy Controlled Trial

    September 2026 in “ Journal of Cosmetic Dermatology ”
    Muhammad Asad Ejaz Chaudhry, Bushra Muneeb, Safoora Aamir … Shoaib Ashraf
    Studysummary This randomized controlled trial found that both topical and low-dose oral minoxidil improved androgenetic alopecia, but did not establish non-inferiority or equivalence between the treatments.
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    Research cited in this study 14

    1. Rethinking Oral Minoxidil: Distinguishing the Hair-Growth Window from the Cardiovascular Threshold Journal of the American Academy of Dermatology · 2026
    2. Summation and Recommendations for the Safe and Effective Use of Topical and Oral Minoxidil Journal of the American Academy of Dermatology · 2025
    3. Efficacy and Safety of Oral Minoxidil Versus Topical Solution in Androgenetic Alopecia: A Meta-Analysis of Randomized Clinical Trials International Journal of Dermatology · 2024
    4. Oral Minoxidil Versus Topical Minoxidil for Male Androgenetic Alopecia JAMA dermatology · 2024
    5. Efficacy and Safety of Low-Dose Oral Minoxidil in the Management of Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2024
    6. Clinical Efficacy and Safety of Low-Dose Oral Minoxidil Versus Topical Solution in the Improvement of Androgenetic Alopecia: A Randomized Controlled Trial Journal of Cosmetic Dermatology · 2023
    7. Low-Dose Oral Minoxidil for Alopecia: A Comprehensive Review Skin appendage disorders · 2023
    8. A Randomized Clinical Trial on Therapeutic Effects of 0.25 mg Oral Minoxidil Tablets on Treatment of Female Pattern Hair Loss Dermatologic Therapy · 2021
    9. Minoxidil: A Comprehensive Review Journal of Dermatological Treatment · 2021
    10. Male and Female Pattern Hair Loss: Treatable and Worth Treating Cleveland Clinic Journal of Medicine · 2021
    11. Safety of Low-Dose Oral Minoxidil for Hair Loss: A Multicenter Study of 1404 Patients Journal of The American Academy of Dermatology · 2021
    12. Minoxidil 1 mg Oral Versus Minoxidil 5% Topical Solution for the Treatment of Female-Pattern Hair Loss: A Randomized Clinical Trial Journal of The American Academy of Dermatology · 2019
    13. Characterization of Follicular Minoxidil Sulfotransferase Activity in a Cohort of Pattern Hair Loss Patients from the Indian Subcontinent Dermatologic Therapy · 2018
    14. Androgenetic Alopecia: New Insights Into the Pathogenesis and Mechanism of Hair Loss F1000Research · 2015