TLDR Lichen Planus in siblings may be influenced by genetics and environment.
This study examines three siblings from an Iranian family, each diagnosed with different variants of Lichen Planus (LP): Lichen Planus Pigmentosus, Lichen Planopilaris, and Frontal Fibrosing Alopecia. The siblings, aged 50 to 60, showed symptoms like facial pigmentation, scalp erythema, and hairline recession. The study suggests potential genetic and environmental factors in LP's pathogenesis, as such familial multivariant cases are previously unreported. Treatments varied, including topical corticosteroids and finasteride, with all siblings achieving remission at a 9-month follow-up. The findings indicate a need for further research into the genetic components of LP.
13 citations
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April 2022 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” The document concludes that more research is needed to find effective treatments for Lichen planopilaris and Frontal fibrosing alopecia.
8 citations
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November 2018 in “Australasian Journal of Dermatology” Frontal fibrosing alopecia in families shows similar signs to individual cases and may have a genetic link.
94 citations
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October 2017 in “International Journal of Dermatology” Lichen planus pigmentosus causes dark skin patches and is treated by avoiding triggers and using anti-inflammatory medications.
33 citations
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January 2015 in “Journal of Cosmetic Dermatology” Familial frontal fibrosing alopecia affects premenopausal women too, and early diagnosis is important, but no proven medication exists yet.
12 citations
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January 2015 in “Indian Journal of Dermatology, Venereology and Leprology” A mother and daughter with similar hair loss conditions and identical HLA types suggest a genetic link between the conditions.
126 citations
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April 2006 in “International Journal of Dermatology” The conclusion is that FFA and LPP have similar scalp biopsy features, making them hard to distinguish histologically, and FFA may be a specific kind of scarring hair loss.
2 citations
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January 2015 in “Springer eBooks” Early diagnosis and aggressive treatment are crucial for Cicatricial Alopecia, and treatment effectiveness varies among patients.
A rare case of a woman having both lichen planus pigmentosus and classic lichen planopilaris at the same time.
13 citations
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April 2022 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” The document concludes that more research is needed to find effective treatments for Lichen planopilaris and Frontal fibrosing alopecia.
November 2023 in “Indian Journal of Dermatology” The study found that Frontal Fibrosing Alopecia in North-East India mainly affects middle-aged women and is often associated with lichen planus pigmentosus.
1 citations
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January 2021 in “Dermatology online journal” A unique case showed a rare combination of two types of lichen planus on the face.
The article suggests that patients with Frontal Fibrosing Alopecia may have more contact allergies, but it doesn't prove that allergies cause the condition.
