Flat Mount Imaging of Mouse Skin and Its Application to the Analysis of Hair Follicle Patterning and Sensory Axon Morphology

    June 2014 in “ Journal of Visualized Experiments ”
    Hao Chang, Yanshu Wang, Hao Ran Wu, Jeremy Nathans
    Studysummary This protocol shows how mouse skin can be prepared as a flat mount to visualize skin structures in detail without physical sectioning.
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    Research cited in this study 9

    1. Responses of Hair Follicle–Associated Structures to Loss of Planar Cell Polarity Signaling Proceedings of the National Academy of Sciences of the United States of America · 2013
    2. Hairy Tale of Signaling in Hair Follicle Development and Cycling Seminars in cell & developmental biology · 2012
    3. The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons Cell · 2011
    4. The Basement Membrane Of Hair Follicle Stem Cells Is A Muscle Cell Niche Cell · 2011
    5. When Whorls Collide: The Development of Hair Patterns in Frizzled 6 Mutant Mice Development · 2010
    6. Order From Disorder: Self-Organization In Mammalian Hair Patterning Proceedings of the National Academy of Sciences · 2006
    7. The Hair Cycle Journal of Cell Science · 2006
    8. Exploiting the Keratin 17 Gene Promoter to Visualize Live Cells in Epithelial Appendages of Mice Molecular and Cellular Biology · 2005
    9. Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis Development · 2003