Hypoxia Macrophage-Derived Exosomal miR-26b-5p Targeting PTEN Promotes the Development of Keloids

    January 2024 in “ Burns & Trauma
    Siya Dai, Mingyuan Xu, Qianqian Pang … Jinghong Xu
    Studysummary The researchers reported that exosomes from hypoxic M2 macrophages, enriched with miR-26b-5p, promoted proliferation, migration, and invasion in human keloid fibroblasts through the PTEN-PI3K/AKT pathway, highlighting miR-26b-5p's role in keloid development.
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    Research cited in this study 2

    1. Recent Understandings of Biology, Prophylaxis, and Treatment Strategies for Hypertrophic Scars and Keloids International journal of molecular sciences · 2018
    2. Epithelial–Mesenchymal Transition in Keloid Tissues and TGF-β1–Induced Hair Follicle Outer Root Sheath Keratinocytes Wound repair and regeneration · 2015