High Doses of Cobalt Inhibited Hair Follicle Development in Rex Rabbits

December 2019 in “ World rabbit science ”

Lei Liu, Gao Qingrong, C. Wang, Zhiren Fu, K. Wang, F. C. Li

cobalt hair follicle development BMP2 BMP4 mTOR ribosomal protein S6 kinase p-mTOR p-ribosomal protein S6 kinase mTOR-BMP signaling pathway

TLDR High doses of cobalt stopped hair growth in rabbits.

The study on 180 Rex rabbits found that high doses of cobalt (6.4 mg/kg) significantly inhibited hair follicle development by decreasing hair follicle density and increasing BMP2 and BMP4 gene expression in skin tissue. Lower cobalt levels had no effect. The inhibition was linked to suppressed protein levels of p-mTOR and p-ribosomal protein S6 kinase, indicating that high cobalt concentrations affected hair follicle development through the mTOR-BMP signaling pathway.

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