Hydroxychloroquine Modulates the Progression of Experimentally Induced Benign Prostatic Hyperplasia in Rats via Targeting EGFR/ERK/STAT3 and AR/FOXO1/TRAIL Pathways: Computational and In Vivo Studies

    June 2025 in “ Scientific Reports ”
    Walaa H. El-Maadawy, Ehab Hafiz, Samer A. Tadros … Yasmin M. Attia
    Studysummary In this study on testosterone-induced benign prostatic hyperplasia in rats, hydroxychloroquine significantly reduced prostate-related markers and enhanced therapeutic effects when combined with finasteride, suggesting potential as a new treatment approach.
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    Research cited in this study 3

    1. Comparison of Combination Therapy With Tamsulosin and Dutasteride or Finasteride in Patients With Benign Prostatic Hyperplasia: A Randomized Clinical Trial African Journal of Urology · 2024
    2. Persistent Gynecomastia Due to Short-Term Low-Dose Finasteride for Androgenetic Alopecia JCEM case reports · 2024
    3. Finasteride-Induced Gynecomastia: Case Reports and Review Indian Journal of Dermatology, Venereology and Leprology · 2009