Hair-follicle associated pluripotent (HAP)-cell-sheet implantation enhanced wound healing in diabetic db/db mice

    June 2024 in “ PLoS ONE ”
    Ayami Hasegawa-Haruki, Koya Obara, Nanako Takaoka, Kyoumi Shirai, Yuko Hamada, Nobuko Arakawa, Ryoichi Aki, Robert M. Hoffman, Yasuyuki Amoh
    TLDR HAP-cell-sheets improved wound healing in diabetic mice.
    The study investigated the effects of hair-follicle-associated pluripotent (HAP) cell sheets on wound healing in diabetic db/db mice. HAP cells, derived from mouse hair follicles, were shown to enhance fibroblast migration and proliferation in vitro. In vivo, HAP-cell-sheet implantation in 10 mm wounds on diabetic mice facilitated wound closure by day 16, increased epithelium thickness and granulation tissue volume by day 7, and promoted early macrophage activity while reducing inflammation. Enhanced angiogenesis was observed in the implanted tissues. These findings suggest that HAP-cell-sheets could be a promising treatment for chronic diabetic ulcers.
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