H3K9me3 Controls Epidermis Morphogenesis by Regulating RNA Polymerase II Dynamics at Developmental Promoters and Enhancers

    May 2026 in “ Nature Communications ”
    Chris Ke Bai, Gopal Chovatiya, Emily Janine Pollack … Tudorita Tumbar
    Studysummary This study observed that the loss of H3K9me3, via the ablation of Suv39h1, Suv39h2, and Setdb1 in embryonic mouse epidermis, disrupts skin development processes such as keratinocyte differentiation and hair follicle formation, highlighting H3K9me3's crucial role in epidermal morphogenesis.
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    Research cited in this study 6

    1. Stem Cell Activity-Coupled Suppression of Endogenous Retrovirus Governs Adult Tissue Regeneration Cell · 2024
    2. Histone H3 K4/9/27 Trimethylation Levels Affect Wound Healing and Stem Cell Dynamics in Adult Skin Stem Cell Reports · 2019
    3. Signaling Couples Hair Follicle Stem Cell Quiescence With Reduced Histone H3 K4/K9/K27me3 for Proper Tissue Homeostasis Nature communications · 2016
    4. Epidermal Development in Mammals: Key Regulators, Signals from Beneath, and Stem Cells International Journal of Molecular Sciences · 2013
    5. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    6. Skin Abnormalities Generated by Temporally Controlled RXRα Mutations in Mouse Epidermis Nature · 2000