Role of Topical Tofacitinib in Autoimmune Skin Disorders: An Expert Opinion

    September 2024 in “ IP Indian Journal of Clinical and Experimental Dermatology ”
    Kiran Godse, Mukesh Girdhar, Soumya Jagadeesan, Ritu Laiker
    Studysummary This source discusses the potential of topical JAK inhibitors, like tofacitinib, as effective treatments for autoimmune skin diseases, emphasizing their superior safety profile and minimal adverse effects compared to conventional systemic therapies.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 11

    1. Alopecia Areata: Burden of Disease, Approach to Treatment, and Current Unmet Needs Clinical, Cosmetic and Investigational Dermatology · 2023
    2. Alopecia Areata in Latin America: Where Are We and Where Are We Going? Dermatology and Therapy · 2022
    3. An Overview of JAK/STAT Pathways and JAK Inhibition in Alopecia Areata Frontiers in immunology · 2022
    4. Unmet Medical Needs in Chronic, Non-Communicable Inflammatory Skin Diseases Frontiers in medicine · 2022
    5. Janus Kinase Inhibitors in Dermatology: General Considerations and Applications in Vitiligo and Alopecia Areata Actas Dermo-Sifiliográficas · 2021
    6. The Emerging Role of Janus Kinase Inhibitors in the Treatment of Autoimmune and Inflammatory Diseases ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2020
    7. Emerging Topical and Systemic JAK Inhibitors in Dermatology Frontiers in Immunology · 2019
    8. A Pilot Study of 2% Tofacitinib Cream with Narrowband Ultraviolet B for the Treatment of Facial Vitiligo Journal of The American Academy of Dermatology · 2019
    9. Topical 2% Tofacitinib for Children with Alopecia Areata, Alopecia Totalis, and Alopecia Universalis Journal of the American Academy of Dermatology · 2018
    10. Tofacitinib 2% Ointment, a Topical Janus Kinase Inhibitor, for the Treatment of Alopecia Areata: A Pilot Study of 10 Patients Journal of the American Academy of Dermatology · 2017
    11. JAK Inhibitors in Dermatology: The Promise of a New Drug Class Journal of the American Academy of Dermatology · 2017