Ginsenoside Rg3 Up-regulates the Expression of Vascular Endothelial Growth Factor in Human Dermal Papilla Cells and Mouse Hair Follicles
December 2013
in “PTR. Phytotherapy research/Phytotherapy research”
TLDR Ginsenoside Rg3 may help hair growth by increasing a growth-related protein in hair cells.
The study investigated the effects of ginsenoside Rg3, a component of Panax ginseng, on hair growth by examining its impact on the expression of vascular endothelial growth factor (VEGF) in human dermal papilla (DP) cells and mouse hair follicles. The researchers found that treatment with Rg3 resulted in a dose-dependent increase in VEGF mRNA and protein expression levels in human DP cells, as measured by real-time polymerase chain reaction and immunohistochemistry. Additionally, immunohistochemical assays revealed that Rg3 significantly up-regulated VEGF expression in mouse hair follicles in a dose-dependent manner. The study also observed an up-regulation of stemness markers CD8 and CD34 in mouse hair follicles treated with Rg3. These findings suggest that Rg3 may promote hair growth by stimulating hair follicle stem cells, indicating its potential for use in hair growth products.
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