Defects in Mitochondrial DNA Replication and Oxidative Damage in Muscle of mtDNA Mutator Mice

    October 2014 in “ Free radical biology & medicine
    Jill E. Kolesar, Adeel Safdar, Arkan Abadi, Lauren MacNeil, Justin D. Crane, Mark A. Tarnopolsky, Brett A. Kaufman
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    Studysummary This study found that oxidative damage is present in the mitochondria of PolG mice, which exhibit premature aging-like phenotypes due to mitochondrial dysfunction.
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