Finasteride and Suicide: A Postmarketing Case Series

    January 2020 in “ Dermatology ”
    Michael S. Irwig
    Studysummary This study suggests that men under 40 who develop persistent sexual side effects and insomnia after using finasteride for alopecia may be at increased risk of suicide.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 19

    1. The 5α-Reductase Inhibitor Finasteride Increases Suicide-Related Aggressive Behaviors and Blocks Clozapine-Induced Beneficial Effects in an Animal Model of Schizophrenia Physiology & Behavior · 2018
    2. Neuroactive Steroid Levels and Psychiatric and Andrological Features in Post-Finasteride Patients The Journal of Steroid Biochemistry and Molecular Biology · 2017
    3. Association of Suicidality and Depression With 5α-Reductase Inhibitors JAMA Internal Medicine · 2017
    4. Persistent Erectile Dysfunction in Men Exposed to 5α-Reductase Inhibitors, Finasteride, or Dutasteride PeerJ · 2017
    5. Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss The Journal of Clinical Endocrinology and Metabolism · 2016
    6. An Observational Retrospective Evaluation of 79 Young Men with Long-Term Adverse Effects After Use of Finasteride Against Androgenetic Alopecia International Journal of Andrology · 2016
    7. Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low-Dose Finasteride: A Pharmacovigilance Study Pharmacotherapy · 2015
    8. Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia: A Meta-Analysis PubMed · 2015
    9. Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride American Journal of Men's Health · 2014
    10. Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation The Journal of Steroid Biochemistry and Molecular Biology · 2014
    11. The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer, and Depression Korean Journal of Urology · 2014
    12. Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology The Journal of Sexual Medicine · 2013
    13. Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects The Journal of Clinical Psychiatry · 2012
    14. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
    15. Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010
    16. Finasteride Treatment Inhibits Adult Hippocampal Neurogenesis in Male Mice Pharmacopsychiatry · 2010
    17. Finasteride Induced Depression: A Prospective Study BMC clinical pharmacology · 2006
    18. Hippocampal 3α,5α-THP May Alter Depressive Behavior of Pregnant and Lactating Rats Pharmacology Biochemistry and Behavior · 2004
    19. Changes in Progesterone Metabolites in the Hippocampus Can Modulate Open Field and Forced Swim Test Behavior of Proestrous Rats Hormones and Behavior · 2002

    Related research 2

    1. Sexual Adverse Effects of Finasteride 1mg for Treatment of Androgenic Alopecia in Men Scripta Scientifica Vox Studentium · 2017
    2. 5α-Reductase Inhibitors in Androgenetic Alopecia Current Opinion in Endocrinology, Diabetes and Obesity · 2014